This could be a really interesting one as Tier 5 pace-setters Sychdyn United host illustrious Lex, promoted to Tier 3 this season but struggling.
Sychdyn are top of North East Wales League Division 2 after wins over Yr Wyddgrug and Cefn Druids, while the Lawmen, who have lost numerous key players over the summer, are one off the bottom of Ardal North East with a draw and four defeats from their five matches.
If Seb Kidd stays on form in front of goal for the Wrexham visitors he could be a vital figure, but watch out for Sychdyn’s early sharp-shooters Adam Woosey and Ewan Whitley.
An all-tier 3 battle at Parc Meurig could end up a cracker.
NFA have kicked off their second season in Ardal North West really well – unbeaten in five with two wins and three draws, while Pesda have taken just three points from their first four outings.
Two newly-named clubs from places steeped in impressive football history meet in the nation’s premier club knockout competition.
Bangor are top of Tier 3 Ardal North West, while Conwy lie fourth in the Tier 4 North Wales Coast East Premier.
Can 1876 top-scorer Corrig McGonigle wreck his former club’s dreams of a giant-killing?
With Porthmadog third in Ardal North West after four straight wins and probably the most famous club involved in this stage of the competition, this has to be classed as a glamour tie for Tier 4 hopefuls Amateurs.
Llandudno have banged in 20 goals in their first four games, with the likes of attackers Jay Sutton and Morgan Thomas capable of making life difficult for Port.
However, the Llŷn Peninsula visitors possess so many goal threats themselves. With strikers such as Jonny Bravo and Rhys Alun on call, they must be classed as favourites.
Nonetheless, Port have already been victims of one upset this season when Tier 4 Nefyn United knocked them ouf ot the FAW Amateur Trophy on penalties.
Two of Anglesey’s top clubs clash at Cae Bob Parry in an all-Tier 3 Ardal North West tussle.
Cefni are unbeaten to date, while Bay lie mid-table.
When these two met last season, Trearddur won 2-1 at Town, but Llangefni gained revenge by beating their opponents away by the same score.
After scoring five at home in an 8-0 demolition of Penmaenmawr recently, Osian Jones could be a real danger for Cefni, while Trearddur front man Josh Stanley will be out to punish his former club.
One of the ties of the round is on the cards at The Ring when Ardal North West Llay host Cefn Albion, currently second in Ardal North East.
This Wrexham-area derby has the makings of a classic.
Cavan Daley has been electric so far for the Welly this season up front, while Alex Williams is in magical form for the Cefners with seven goals in four matches to date.
CPD Sychdyn United v Lex XI (6.45 pm)
Welshpool Town v Four Crosses (7.30 pm)
Bethesda Athletic v NFA
Bow Street v Penycae
CPD Cerrigydrudion v FC Queen’s Park
Conwy Borough Swifts v CPD Dinas Bangor City 1876
Corwen v Broughton United
Dolgellau AA v Llanidloes Town
Forden United v Llanrwst United
Greenfield v Berriew
Kinmel Bay v Llangollen Town
CPD Llanberis v Llansantffraid Village
Llandudno Amateurs v Porthmadog
Llanfair United v Cemaes Bay
Llangefni Town v Trearddur Bay
CPD Llannerchymedd v Rhayader Town
Llanrug United v Gwalchmai
Llay Welfare v Cefn Albion
Machynlleth v CPD Llannefydd
Penmaenmawr Phoenix v CPD Nefyn United
Pwllheli v Knighton Town
Rhos United v Hawarden Rangers
Rhostyllen v Nantlle Vale
Saltney Town v Coedpoeth United
CPD Y Glannau v St Asaph City
New Zealander Jacob Duker will be out to make an impression for Hawarden Park at…
Ardal North West champions CPD Dinas Bangor City 1876 (blue strip) play their final league…
It's a league title treble for Wrexham-based club FC Queen's Park! On Friday evening, the…
Jamie Reed (blue) scored Bangor City 1876's second goal against Penmaenmawr on Wednesday. Pictures: MATT…
Andy Clarke of CPD Aberffraw has passed the 30-goal mark for the season. Picture: WYNNE…
CPD Pwllheli - Tim Datblygu (white) in action during their weekend victory over West Division…