Soloman Moore (2), Riley Cranham and Thomas Wardle split the goals which sealed the win that edged Mochdre up to third in the table.
Ben Lewis’ 88th minute equaliser rescued a point for Y Glannau after Charlie McIlvogue had given Penmaenmawr the lead on 54.
Damien Smith (2) and Jac Bee (penalty) secured victory for Bont, Jay Jones replying for Gaerwen when they were 2-0 down.
Ruthless display from Pwllheli who were seven-up at half time.
Osian Williams scored four for the visitors, Jason Banks adding a hat-trick, one a penalty, Jamie Underwood dished out a double and Cian Goodman Shephard added a single.
Jamie Williams netted a consolation for outgunned Wanderers.
George Pierce notched the fourth-minute goal which was sufficient to send Henllan through to the next round.
Shaun Morris (2), Owen Jones, Joshua Calvert (penalty), Leon Buckland and Llyr Williams made the scoresheet entries that confirmed a big cup win for Llandegai, David Zmiarowski with a single response for Sports.
Carter Davies (3), Aaron Tocker (2) and Tomos Jones brought up the half-dozen for victorious Vale, Liam Miller and Ross Thomas on target for the Rhyl-based visitors.
Shock on Anglesey as Pentraeth eliminated Kinmel Bay in a penalty shoot out.
Christian Akoha gave Bay a 37th minute lead, but Sion Jones levelled matters early in the second half.
Goalkeeper Cian Taylor was the Pentraeth hero as the islanders prevailed on spot kicks.
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