Pentraeth remain top of Division One despite losing their 100% record and having a three-match winning streak halted by Llanfairpwll on Saturday.
All the goals came in the closing 10 minutes at Maes Eilian, Cai Griffiths putting the Sandmen in front on 80 before Tomos Williams levelled after 82 and Dei Thomas grabbed the winner with 88 gone.
Amlwch celebrated their first league win of the campaign at the expense of bottom side Borough.
Sub Dan Howes put the hosts in front on 27, just three minutes after replacing Chris Byast.
In remained 1-0 until the 92nd minute when Tam Morton doubled the lead, Howes this time assisting.
Aaron Jones knocked in a 91st minute winner for Cefni at Cae Bwthyn.
The visitors took a two-goal lead, Macauley Lewis and Kieran Owen on target after 28 and 31 minutes respectively, but Dafydd Jones hit back for the hosts before the break.
When Jones levelled in the 57th minute from a Kaden Nisbet assist it was very ,much game on.
The rest of the match proved fiercely competitive, but it was Cefni who sealed it when Aaron Jones benefited from a Tommy Roberts assist.
New signing Jamie Patterson made it a dream debut when he grabbed a 90th minute decider for his latest club Llanerchymedd.
Signed last week from Gaerwen for his goal-getting ability, Patterson made a great early impression with his winning strike at Tan Parc.
Dion Owen provided the assist for the crucial goal and also scored two himself in a superb performance. Medd fought back from two-down to win the day.
Herbie Hofsteede opened the scoring for Bethesda Rovers in the 30th minute and 1-0 was the half time score.
In the 47th minute, Hofsteede made it a double for the fourth consecutive match to put the visitors in seeming command.
Llanerchymedd began the fightback on 61 minutes when Patterson set up captain Owen to make it 2-1.
Owen equalised on 83 and then provided the assist for Patterson to bag the winner in a cracking game of football.
Mountain Rangers made it two wins out of two with a convincing success at Tyddyn Paun.
It was a case of the super subs creating all the magic, with Caernarfon Town legend Nathan Craig scoring twice for the visitors on 77 and 86 minutes, his first from the penalty spot.
Replacements Daniel Owen and Dylan Owen added the other two goals.
Chris Byast put Amlwch Town in front, but Pentraeth hit back to take the points courtesy of subs Ryan Shaw and Hogr Tofigy.
All-square at Treborth, Guto Gwenallt giving Llanystumdwy a 12th minute lead, but Dylan Williams levelled from the penalty spot on 65.
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