Llandudno Albion, the 2019-20 FAW Trophy finalists, have landed a home draw against fellow Ardal North West side Llanrwst United in the last 32 of the 2021-22 competition.
The teams met recently in league combat at Parc Gwydir, the Roosters winning 2-0.
Tier 4 giant-killers Menai Bridge Tigers have scooped a home meeting with former Welsh Premier League club Caersws, now of the third-tier.
Bangor 1876 face a testing trip to Llannefydd, while 2018-19 winners Cefn Albion face Porthmadog in what could be the tie of the round.
Another nine ties make up the southern section of the round four draw.
Berriew v Mynydd Llandegai
Bodedern Athletic v Penrhyndeudraeth
Cefn Albion v Porthmadog
Llandudno Albion v Llanrwst United
Llangollen Town v Mold Alexandra
Llannefydd v Bangor 1876
Menai Bridge Tigers v Caersws
Ties to be played on Saturday, September 11