With Druids on a run of three straight league wins and Barry having lost their last two, after going undefeated in their first 11, it would be no surprise to see a home victory at The Rock.
Barry did the double over the Ancients last season while Cefn did the same to the South Walians the campaign before.
Earlier this term, Barry claimed a 1-0 triumph in the reverse fixture at Jenner Park.
Gavin Chesterfield’s side will be keen to avoid another defeat which would cost them more ground in the title race. Barry are currently still second in the table, with Druids down in eighth.
Third-from-bottom hosts fourth-from-top in what is always an attractive fixture in the Cymru North calendar.
Rhyl will travel to the Traeth on the back of a good 4-1 league win on Tuesday over Buckley Town.
Last season the Lilywhites ran out 3-1 victors at the Traeth.
Port will gain confidence from their 4-1 Welsh Cup success over Gresford last weekend – their best performance of the campaign by some distance.
Sion Eifion Jones’ side had been showing much improved league form before losing at home to fellow strugglers Corwen last time out. They know they must perform much better against Rhyl than in that game if they are to trouble their visitors.
A really fascinating clash on the cards.
Llannefydd are eighth in Welsh Alliance Division Two, but could go top if they won their games in hand on the leaders.
Nefyn have performed really well in the Gwynedd League, holding table-toppers Trearddur Bay Bulls to a draw last weekend, pulling off some giant-killings and giving Bangor City a major test in the Welsh Cup.
Having crashed out of the Welsh Cup so heavily at Mold last weekend, Llanrug will want to put things right at Welsh National League hosts Llanuwchllyn.
It looks like a fairly even tie at the Bala area ground, with Llanuwchllyn sixth in the WNL Premier and Rug 11th in Welsh Alliance Division One, but capable of much higher.
Whatever the odds, you can never bet against Llanrwst causing an upset – they have produced too many shocks over the years to ever dismiss them.
The Rwsters have a battle on their hands against Hotspur, second in Division One and just one loss in nine, as well as being top-scorers, but Leighton Griffiths’ men, whose home form has been disappointing, are in a handy sixth themselves. Could end up a draw.
Saltney will be out for revenge having lost 3-1 at home to Mold in the Welsh Trophy in September.
Alex are flying, thrashing teams right, left and centre, especially in the cups of late.
The only reason Mold are as low as seventh in the Premier is because they have played less games than everyone else. They’ve lost just the once in the league and will be favourites to see off Saltney, but the Bordermen are never a pushover.
Interesting little contest this one.
Llysfaen, undefeated in Division One, won six, drawn one and a massive 43 goals scored against a Cernyw outfit also showing well in the Premier in fourth spot.
After being brought down to earth – albeit in gallant fashion – with back-to-back defeats in the FAW Trophy and Welsh Cup by much higher-ranked opposition, 1876 return to bread and butter knockout this Saturday.
Llanystumdwy have shown snatches of decent form this term, but it could be very hard for them at Treborth.
Bangor 1876 manager Mel Jones and assistant Dylan Williams’ plans for the remainder of the season suffered a body blow earlier in the week with the news of the retirement of experienced midfielder Iwan Williams on medical advice.
The highly respected UEFA Pro Licence coach suffered a ruptured Achilles, broken tibia and metatarsal during the opening minutes of last weekend’s Welsh Cup loss to Ruthin Town.
Missing through suspension last weekend but expected to resume his central striking role on Saturday is influential forward Les Davies.
With several players carrying minor injuries and niggles, the management duo may well opt to reshuffle the pack in choosing their starting line-up on Saturday.
The reward for the winners is an away tie against either Menai Bridge Tigers or Talysarn Celts in the next round on Saturday, 7 December (main preview info: Kevin Owen).
These two played out a pair of cracking battles in September.
Albion pulled off an upset 2-0 victory at Pen in the Premier Cup, then they met again seven days later in the league at Borras and it finished 4-4.
On those outcomes, Penyffordd will look on Saturday’s return league fixture as an opportunity for revenge. Lions are third and Albion fifth, one point only apart.
Sixth versus second in the Anglesey League.
After a recent shock home defeat to Holyhead Hotspur Reserves in the Megan Cup, Rangers will be anxious not to exit another competition, but Pentraeth are never easy to beat.
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