Vale stormed to the Premier summit with a six-goal caning of Llanberis at Maes Dulyn.
The hosts were in total control by half time, a double from the ever-prolific Ashley Owen, plus Owain Ellis and Osian Jones singles giving them a four-goal cushion.
Llion Griffiths and sub Osian Tomilnson added further goals in the second half.
A tremendous clash is in store on November 15 when top two Nantlle Vale and Menai Bridge clash at Penygroes.
A second point of the season for bottom side Gwalchmai.
Evergreen front man James Burgess got Gwalch off to a flyer with a fourth-minute goal, but Iwan Jones levelled on 13 from a Joe Dukes-Morgan assist.
Although Medd took a two-goal lead at Tan Parc, Nefyn turned the tables in the second half.
Dion Owen edged the hosts in front on two minutes and a Iwan Moore own goal after nine handed the Anglesey side a handy lead.
However, Tomi Jones Evans pulled one back before the break and added two more in the second period to reach 12 goals for the season.
Josh Piper and sub Llyr Williams also made the scoresheet for the third-placed Penwaig in the second 45.
Sub Guto Wyn Hughes bagged a 92nd minute winner for 10-man Talysarn in a cracker at Eithin Duon.
Llanrug led 3-2 at the interval, Kevin Lloyd (2, 1 pen) moving up to 13 goals for the campaign and Matthew Roberts also on target, Aled Jones and Gethin Wyn Jones responding.
Jac Pearce Jones equalised on 63, then on 83 Talysarn had Tomos Williams dismissed for a second yellow.
However, Celts overcame having a man less to deliver that Hughes decider.
Recent signing Tomos Williams scored twice – his first goals for Boded – in the second half to clinch three points for the Ynys Môn side.
Chris Jones set the ball rolling for the visitors, taking advantage of a Williams assist to hand his team a half-time lead.
Williams’ pair sealed it for Boded, Zac Williams notching a consolation for Llandegai.
Corey Hughes of the away side was red-carded in the 85th minute.
Aeron Wyn Williams grabbed the all-important 59th minute goal which banked maximum points for Rangers.
A fifth straight win in all competitions nudged the Cae Gors outfit up to fifth place.
Both goals came in the second half at Cae Dros yr Aber. captain Arwyn Price putting Deiniolen ahead on 57 minutes via the penalty spot before Cian Pleming clinched the victory on 90+1, sub Kieran Georgenson with the assist.
Jordan Pritchard was a hat-trick hero for third-place Gaerwen.
Pritchard struck on 21, 82 and 85 minutes, Callum Hughes with two assists and Jay Finter supplying one, Ioan Sandison and Anthony Williams adding further scoresheet entries for the Auctioneers, now unbeaten in five league games.
Kian Abbott replied for the Sandmen.
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