Callum Moore’s 89th minute winner settled a seven-goal cracker in Hotspur’s favour.
Robert Thomas gave the Holy Islanders a seventh-minute lead, but Harry Lea soon equalised and James Thomas made it 2-1 to Denbigh before the quarter-hour.
Robert Thomas struck again after half-an-hour to make it 2-2 at the interval.
James Thomas put Denbigh in front again on 64 minutes, but Joshua Evans levelled it after 80 and then Moore sealed it on 89.
Two first half goals secured the points for Holywell, who remain unbeaten at the summit after 12 games.
Ashley Davies, on three minutes, and a rocket from Aidan Bell after 26 put the Wellmen two-up at the interval.
Aron Hughes pulled one back from the penalty spot for Llanrwst on 73 minutes.
All five goals came in the second half for second-place Ruthin against the bottom side.
A brace apiece by Dan Dolben and Josh Jones and an Alun Vaughan single made it a good day for Jamie Hulse’s team.
Will Hughes (2, 1 pen) and Ben Roberts led Bala to a fine win at Maesdu Park, Dion Wyn Lloyd responding for the hosts.
Caernarfon Town's Noah Edwards (right) up against Holywell's Owen Davies at The Oval. Picture: SAM…
NFA (sky blue) in recent action against Denbigh Town. Can the Rhyl side beat Pwllheli…
Coedpoeth United were the stars of Welsh Cup round two FAW WELSH CUP ROUND 3…
Former Conwy Borough manager Ronnie Green has joined Northern Premier League West Division club Runcorn…
Jess Jones (blue) was on target for Llangefni Town at NFA last weekend. Picture: DAI…
New Conwy Borough head coach Paul Issacs. Picture: CONWY BOROUGH FC - with thanks Conwy…