Thomas Miller gave Albion a 10th minute lead at The Muga, but Saints fought back to win and stretch their advantage at the top to nine points.
Rhydian Williams, George Pattenden and Owen Davies scored for the visitors.
Nomads hammered next-to-bottom Rhostyllen at The Quay 3G.
Rafael Endemano (2), Jonathan Sodhi, Alfie Vaughan, William Nash, Dominic Deacon (2), Robbie Jones and Luca Hogan shared the goals.
Jonny Taylor, Evan Edwards, Matthew Grundy and substitute Jordan Rumens scored a goal apiece in a fine win for Llay on a great weekend for the club.
Carwyn Davies responded for Rhos Aelwyd.
Matthew Lewis put Hotspur in front at Y Morfa in the 14th minute, but Ben Ahari levelled after 28 and Matthew Baldock netted the winner on 86.
A fine win on the road for Llangefni, who led 2-0 at the break through goals from Jack Edwards and Sion Jones.
Ben Owen added a third on 51 minutes and Harry Jones completed the scoring after 85.
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