Newly-formed Rovers, playing their first-ever competitive game, looked capable of giving Caergybi a real fright when they led 3-2 at half time.
However, the visitors turned up the heat after the break to score seven goals without reply.
Osian Price got the Bethesda hosts off to a flyer with an eighth-minute opener, but Gary Jo-Owen levelled from the spot and top-scorer Louis Chapman soon made it 2-1.
The hosts were undeterred, however, Reece Williams equalising on 20 minutes and Jack Astbury put Rovers in front after 28.
The second half was a different tale as Caergybi awoke from their slumber and piled on the goals.
Chapman completed his hat-trick within 10 minutes of the second period and later hit a fourth to move onto 16 goals for the campaign.
Midfielder Dave Webb weighed in with a double and before the end Sion Thomas and Jamie Beck put the visitors well out of sight.
After an unexpected shaky start to the season Bethesda came good with a seven-goal caning of Llangoed at Parc Meurig.
Ally Issa delivered an early goal to calm any nerves which may have been present, but it remained 1-0 up until first half added time, when Adrian Roberts doubled the lead.
Midway through the second period, it was still 2-0, but Mark Hughes’ side then produced a flood of goals.
Joe Todd (pen), Kyle Hartleb, Osian Hughes, Cameron Roberts and Cai Davies brought up the seven.
Not the sort of result Holyhead were looking for as impressive Waunfawr maintained their strong start to 2021-22 with a four-goal triumph at Millbank.
Shaun Roberts’ early double put the Beganifs in command and Guto Llywelyn made it three before half time.
It stayed at 3-0 until David Parry added a late fourth for the travelling outfit.
On a day of mainly big away wins in Division One, Llanfairpwll came up with another when they visited Cae Gors.
Star man Luke Owen struck a first half pair to put the Anglesey side two-up at the changeover.
Cian Owen added a third, and while Mark Williams pulled one back, ‘Pwll’s Marquis Holland, who also missed a penalty, made no mistake when he netted on the hour.
Dylan Williams made it five for the outstanding visitors to complete a resounding display.
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