Mochdre have a six-point lead at the summit after a 10th straight victory.
A goal on 27 minutes from Mathew Shaw put the home side ahead, but three strikes in quick succession after 35, 37 and 45 minutes saw the visitors go in 3-1 up at half time through Solomon Moore, Tom Wardle and Leon Hender. Henllan marksman Shaw was red-carded in first half added time.
The second half saw a number of chances for Mochdre to put the game out of sight but the only goal came for Jac Thomas in the 86th minute with a cheeky back heal over the line.
Sam Parry made it two hat-tricks in three games for a Llandudno side which won comfortably at Maesdu Park.
Parry registered on 3, 30 and 69 minutes for the hosts, while captain Mitchell Knight and Thomas Williamson also found the net.
Six different scorers struck for Glan Conwy in this convincing away success, David Hansom, captain Oliver Carey, William Rylance, plus subs Ryan Boddis (pen), Jack Hoyle and Adam Davies all on the mark.
Captain Craig Richardson and Jamie Williams replied for Wanderers.
Josh Lee (2) and Ollie Clarke shared the goals in Conwy’s victory at Roe Plas Meadows, Ray Knight responding for Saints.
All the goals came in the first half at Cae-y-Glannau, where third-placed Kinmel Bay made it eight wins in nine starts.
Charlie Hill struck first for the visitors on seven minutes before Ben Preater made it two from the penalty spot after 37, Michael Norval hitting back for the hosts on 45.
In the only match of six in the West Division to survive the weather, unbeaten Hotspur made it 10 wins in 11 starts and now head the table by an 11-point margin.
Holyhead have blasted 60 goals in their 11 outings, nine of them coning on Sunday at The New Stadium.
Kane Astles struck four times for the hosts for the second time this term, pushing him up to 13 goals for the campaign.
Casey Gregg added a double, captain Joe Jones a single, and subs Sean Pritchard and Cayden Malone also made the scoresheet.
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